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Formamide product process introduction

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Formamide product process introduction

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  • Angabezeit:2020-02-18 17:15
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QuelleFormamide is a compound, a colorless and transparent liquid with a slight ammonia smell. It is a raw material for synthetic medicine, perfume, dyes, etc. It can also be used as a solvent for the spinning of synthetic fibers, plastic processing, and production of lignin ink. .

Formamide product process introduction

QuelleFormamide is a compound, a colorless and transparent liquid with a slight ammonia smell. It is a raw material for synthetic medicine, perfume, dyes, etc. It can also be used as a solvent for the spinning of synthetic fibers, plastic processing, and production of lignin ink. .

  • Kategorie:News
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  • Angabezeit:2020-02-18 17:15
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Details
Formamide is a compound, a colorless and transparent liquid with a slight ammonia smell. It is a raw material for synthetic medicine, perfume, dyes, etc. It can also be used as a solvent for the spinning of synthetic fibers, plastic processing, and production of lignin ink. .
production method
  method 1
The first step is the formation of methyl formate from carbon monoxide and methanol under the action of sodium methoxide. In the second step, methyl formate is re-aminated to formamide. The reaction conditions are 80-100 ° C and 0.2-0.6MPa. This method has fewer problems.
Method 2
The formic acid and methanol are first esterified to form methyl formate, and then ammonolyzed to form formamide, and then distilled to separate methanol and impurities to obtain a finished product. This method has tended to be eliminated due to high costs.
Method 3
The first step is the direct synthesis of formamide from carbon monoxide and ammonia under the action of sodium methoxide under high pressure (10-30MPa) and temperature of 80-100 .
Method 4
Formic acid and urea method.
Method 5
The first step is the production of ammonium formate from the interaction of formic acid and ammonia. The second part is heated to dehydrate ammonium formate to formamide.
Use
Pyroformamide has active reactivity and special dissolving ability. It can be used as an organic synthetic raw material, a paper processing agent, a softener for the fiber industry, a softener for animal glue, and an analytical reagent for determining the amino acid content in rice. In organic synthesis, there are many uses in medicine, and there are many uses in pesticides, dyes, pigments, fragrances, and auxiliaries.
Amidine is used as an intermediate to synthesize imidazole, pyrimidine, 1,3,5-triazine, caffeine, theophylline, and theobromine. Used as raw materials for dyes, perfumes, pigments, adhesives, textile auxiliaries, paper treatment agents, etc. Raw materials for producing formic acid and dimethylformamide.
Rhenium is also an excellent organic solvent, mainly used in the spinning of acrylonitrile copolymers and ion exchange resins, as well as antistatic coating or conductive coating of plastic products. In addition, it is also used to separate chlorosilanes and purify grease. Formamide can undergo a variety of reactions. In addition to three hydrogens participating in the reaction, dehydration, CO removal, introduction of amino groups, introduction of acyl groups, and cyclization can also be performed.
Take the ring union as an example. Diethyl malonate is cyclized with formamide to obtain 4,6-dihydroxypyrimidine, an intermediate of vitamin B4. Anthranilic acid cyclizes with amide to give an antiarrhythmic often chlorazine intermediate quinazolone-4. 3-amino-4-ethoxycarbonylpyrazole cyclizes with formamide to give xanthine oxidase inhibitor allopurinol . Ethylenediamine tetraacetic acid is cyclized with formamide to obtain the anticancer drug ethyleneimine. The methyl ethyl methoxymalonate is cyclized with formamide to obtain the intermediate -5-methoxy-4,6-dihydroxypyrimidine disodium of sulfa drugs.

 

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